🩸 Chapter 499 · Acquired Pure Red Blood Cell Anemia

Nelson Textbook of Pediatrics 22nd Edition | Transient Erythroblastopenia of Childhood (TEC) — most common acquired red cell aplasia, age 6 mo-3 yr, normocytic anemia, normal eADA, self-limited. Parvovirus B19 aplastic crisis in chronic hemolysis. Persistent infection in immunocompromised.

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📋 30 Clinical Scenarios — Acquired Pure Red Cell Aplasia (TEC, Parvovirus)

📇 High‑Yield Review Cards (TEC & Parvovirus B19)

🩺 Clinical Recognition: Transient Erythroblastopenia vs Parvovirus Aplastic Crisis

Select a presentation for diagnostic clues and differentiation from DBA.

📋 Stepwise Management of Acquired Pure RBC Aplasia

🔑 DBA vs TEC Comparison — Nelson Table 499.1
Diamond-Blackfan (DBA)
Transient Erythroblastopenia (TEC)
Age <1 year (90%)
Age 6 mo-3 yr (peak 1-2 yr)
Macrocytic anemia
Normocytic anemia
Elevated eADA, HbF
Normal eADA, HbF
Congenital anomalies (40-50%)
No anomalies
Chronic, requires treatment
Self-limited, resolves 1-2 mo

    ⚡ Reflex Prompts — Clinical Decisions in Acquired PRCA

    📖 Summary: Acquired Pure Red Cell Anemia — Nelson Ch 499