🧬 Chapter 505 · Other Microcytic Anemias

Nelson Textbook of Pediatrics 22nd Edition | Microcytic anemias not due to iron deficiency: thalassemia traits (Ξ±, Ξ²), sideroblastic anemias (ALAS2, SLC25A38, ringed sideroblasts), copper deficiency (zinc toxicity, malabsorption), lead poisoning (basophilic stippling), hereditary pyropoikilocytosis, infantile poikilocytosis, iron-refractory IDA (IRIDA).

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πŸ“‹ 30 Clinical Scenarios β€” Other Microcytic Anemias (non-iron deficiency)

πŸ“‡ High‑Yield Review Cards (Other Microcytic Anemias)

🩺 Clinical Recognition: Non‑Iron Deficiency Microcytic Anemias

Select a presentation for diagnostic clues and management.

πŸ“‹ Stepwise Diagnostic & Management Approach for Microcytic Anemias (Excluding Iron Deficiency)

πŸ”‘ Differential Diagnosis β€” Microcytosis + Normal/High Ferritin
β€’ Ξ²-thalassemia trait β†’ elevated HbA2 (>3.5%)
β€’ Ξ±-thalassemia trait β†’ normal HbA2, low MCV, genetic testing
β€’ Sideroblastic anemia β†’ ↑ serum iron, ↑ ferritin, ringed sideroblasts on marrow
β€’ Copper deficiency β†’ low serum copper/ceruloplasmin (zinc toxicity)
β€’ Lead poisoning β†’ elevated blood lead, basophilic stippling
β€’ IRIDA β†’ TMPRSS6 mutation, refractory to oral iron

    ⚑ Reflex Prompts β€” Clinical Decisions in Other Microcytic Anemias

    πŸ“– Summary: Other Microcytic Anemias β€” Nelson Ch 505