🦴 Bone & Joint Disorders — Rapid Review

Screening tests, diagnostic tools, most accurate treatments & memorable mnemonics (Nelson Textbook of Pediatrics 22nd Ed). Designed for quick recall & clinical application.

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📌 Orthopedic Growth & Development (Chapter 713)

🔍 Screening

Newborn hip exam (Barlow/Ortolani), routine observation of gait, torsional profile for in-toeing.

🧪 Diagnostic Tests

Clinical exam; radiographs for suspected dysplasia, bone age for growth assessment.

💊 Most Accurate Treatment

Reassurance for physiologic bowing/intoing. Pavlik harness for DDH <6mo.

🧠 Mnemonic

“CUTE” — Cartilage, Ultrasound for DDH, Tibial torsion observation, Epiphysis remodeling.

📌 Orthopedic Evaluation (714)

🔍 Screening

pGALS (gait, arms, legs, spine) for school-age children, limb symmetry, gait observation.

🧪 Diagnostic Tests

Beighton score (hypermobility); neurology exam; radiographs; MRI for soft tissue/occult pathology.

💊 Most Accurate Treatment

Depends on underlying disorder; early physical therapy for motor delay.

🧠 Mnemonic

“SPINE” — S ymmetry, P algation, I nspection, N eurologic, E xam (ROM).

📌 Foot & Toes (715)

🔍 Screening

Newborn foot exam; heel bisector line; clubfoot screening.

🧪 Diagnostic Tests

Radiographs for tarsal coalition (CT gold standard); Ponseti method for clubfoot.

💊 Most Accurate Treatment

Clubfoot: Ponseti casting + tenotomy + abduction bracing. Flexible flatfoot: observation.

🧠 Mnemonic

“CAVE” — Cavus, Adductus, Varus, Equinus (clubfoot components).

📌 Torsional & Angular (716)

🔍 Screening

Foot progression angle, femoral anteversion (prone internal rotation), thigh-foot angle.

🧪 Diagnostic Tests

Physical exam; scanogram for leg length; standing alignment radiographs for Blount.

💊 Most Accurate Treatment

Observation for physiologic bowing (resolves by 3-4y). Blount: bracing or osteotomy.

🧠 Mnemonic

“FIT” — F emoral anteversion (intoing), I nternal tibial torsion, T arget observation.

📌 Leg-Length Discrepancy (717)

🔍 Screening

Galeazzi sign, standing block test, pelvic level.

🧪 Diagnostic Tests

Scanogram, EOS (low-dose), CT for precise measurement, bone age (Greulich-Pyle).

💊 Most Accurate Treatment

Epiphysiodesis for 2-5 cm predicted discrepancy; lengthening for >5 cm (magnetic nail).

🧠 Mnemonic

“BLT” — B lock test, L engthening, T iming (epiphysiodesis by multiplier method).

📌 The Knee (718)

🔍 Screening

Lachman, anterior drawer, McMurray, patellar apprehension.

🧪 Diagnostic Tests

MRI for ACL/meniscus/OCD; radiographs for OCD (tunnel view).

💊 Most Accurate Treatment

ACL reconstruction (physeal-sparing if open physes). OCD: stable → rest; unstable → drilling/fixation.

🧠 Mnemonic

“SNAP” — S napping (discoid meniscus), N on-op ACL?, A pophysitis (Osgood), P atellar instability.

📌 The Hip (719)

🔍 Screening

Barlow/Ortolani (newborn), limited abduction (infant), Trendelenburg gait.

🧪 Diagnostic Tests

Ultrasound (<6mo); radiographs after 4-6mo; MRI for LCPD/AVN.

💊 Most Accurate Treatment

DDH: Pavlik harness (<6mo); LCPD: containment (bracing/osteotomy); SCFE: in situ pinning.

🧠 Mnemonic

“HIP” — H arness (DDH), I n-situ screw (SCFE), P erthes containment.

📌 The Spine (720)

🔍 Screening

Adams forward bend test, scoliometer, neurologic exam.

🧪 Diagnostic Tests

Cobb angle (standing radiograph); MRI for intraspinal anomalies; SPECT for spondylolysis.

💊 Most Accurate Treatment

AIS: bracing 25-45°, surgery >50°. Spondylolysis: rest, PT, TLSO.

🧠 Mnemonic

“BRACE” — B race for curves, R adiographs Cobb, A SSI (spinal fusion), C ongenital MRI, E xtension pain (spondylolysis).

📌 The Neck (721)

🔍 Screening

Head tilt/rotation, SCM mass, cervical ROM.

🧪 Diagnostic Tests

Ultrasound (CMT), dynamic CT (atlantoaxial rotary displacement), MRI spine.

💊 Most Accurate Treatment

CMT: stretching (first 3mo); Klippel-Feil: avoid contact sports; Grisel: traction + collar.

🧠 Mnemonic

“TORT” — T rauma/infection, O rtho (CMT), R otatory displacement, T oughey (Klippel-Feil).

📌 Upper Limb (722)

🔍 Screening

Nursemaid elbow (arm held pronated), polydactyly, thumb hypoplasia.

🧪 Diagnostic Tests

Radiographs; Fanconi workup for radial deficiency; echocardiogram for Holt-Oram.

💊 Most Accurate Treatment

Nursemaid elbow: supination+flexion reduction. Polydactyly: excision 9-12mo. Trigger thumb: A1 pulley release.

🧠 Mnemonic

“RULE” — R adial deficiency screen, U lnar polydactyly, L ittle league elbow rest, E xcision of extra digit.

📌 Arthrogryposis (723)

🔍 Screening

Multiple joint contractures at birth, midface hemangioma (amyoplasia).

🧪 Diagnostic Tests

EMG/nerve biopsy, muscle MRI, genetic testing (MYH3, etc).

💊 Most Accurate Treatment

Ponseti for clubfoot, serial casting, surgical releases, physical therapy.

🧠 Mnemonic

“STIFF” — S erial casting, T endon transfers, I ntact intellect, F eet/knees sequential, F unctional goals.

📌 Common Fractures (724)

🔍 Screening

Ottawa ankle/knee rules, neurovascular exam.

🧪 Diagnostic Tests

Radiographs (AP/lateral/oblique), CT for triplane/Tillaux, MRI for occult fractures.

💊 Most Accurate Treatment

Supracondylar humerus type III: closed reduction + pinning. Femur: age-based (spica, flexible nails).

🧠 Mnemonic

“SHARP” — S alter-Harris, H umerus supracondylar, A cceptable angulation, R emodeling potential, P hysis respect.

📌 Osteomyelitis (725)

🔍 Screening

Fever + focal bone pain + refusal to bear weight (esp. child).

🧪 Diagnostic Tests

MRI with STIR (gold standard), CRP, blood culture, bone aspirate.

💊 Most Accurate Treatment

IV antibiotics (cefazolin/vancomycin) 4-6 wks; surgical drainage if abscess.

🧠 Mnemonic

“MRI C” — M RI early, R esolution CRP, I V then oral switch, C over S. aureus/Kingella.

📌 Septic Arthritis (726)

🔍 Screening

Kocher criteria (fever, non‑WB, ESR>40, WBC>12k).

🧪 Diagnostic Tests

Joint aspiration (WBC>50k), Gram stain, PCR (Kingella). Ultrasound for effusion.

💊 Most Accurate Treatment

Surgical drainage (arthrotomy/arthroscopy) + IV antibiotics (10-14 days).

🧠 Mnemonic

“DR IP” — D rainage, R emember Kocher, I V antibiotics, P CR for Kingella.

📌 Injury Prevention (727)

🔍 Screening

Preparticipation exam (cardiac history, prior injury, heat illness).

🧪 Diagnostic Tests

ECG for syncope/family history; functional screening for ACL risk.

💊 Most Accurate Treatment

Neuromuscular training (ACL prevention), acclimatization, rule enforcement.

🧠 Mnemonic

“SAFE” — S creening (PPE), A cclimatization, F air play, E quipment (helmets).

📌 MSK Injury Management (728)

🔍 Screening

PRICE (protection, rest, ice, compression, elevation).

🧪 Diagnostic Tests

X-ray, MRI for stress fracture/OCD; compartment pressure.

💊 Most Accurate Treatment

4-phase rehab (relative rest → sport‑specific). Compartment syndrome → fasciotomy.

🧠 Mnemonic

“PRICE” — P rotection, R est, I ce, C ompression, E levation (acute).

📌 Concussion (729)

🔍 Screening

SCAT6/Child-SCAT6, symptom checklist, balance mBESS.

🧪 Diagnostic Tests

Clinical diagnosis; CT if red flags; computerized neurocognitive testing.

💊 Most Accurate Treatment

Return‑to‑learn → graduated return‑to‑play (6 stages).

🧠 Mnemonic

“RETURN” — R emove, E valuation, T argeted rest, U pdated plan, R ehabilitation steps, N o same‑day return.

📌 Cervical Spine Injuries (730)

🔍 Screening

Neck pain, neuro deficit, Canadian C‑spine rule.

🧪 Diagnostic Tests

Flexion/extension radiographs, CT for fracture, MRI for cord.

💊 Most Accurate Treatment

Stinger → return if normal. Transient quadriparesis with stenosis → absolute contraindication to contact.

🧠 Mnemonic

“STABLE” — S tener, T ransient quadri, A tlantoaxial, B race?, L oss of lordosis, E mergency MRI.

📌 Heat Injuries (731)

🔍 Screening

Heat index, hydration status, acclimatization.

🧪 Diagnostic Tests

Rectal temperature (core), electrolytes, renal function.

💊 Most Accurate Treatment

Heat stroke: cold water immersion (emergency).

🧠 Mnemonic

“COLD” — C ramp → oral electrolyte, O verheating → ice water, L oss of consciousness → 911, D ehydration prevention.

📌 Nutrition/Endocrine in Athletes (732)

🔍 Screening

Menstrual history, stress fractures, eating attitudes.

🧪 Diagnostic Tests

DXA (Z-score), LH/FSH/estradiol, testosterone, ferritin.

💊 Most Accurate Treatment

Increase energy availability (diet + reduce exercise).

🧠 Mnemonic

“RED-S” — R elative energy deficiency, E ating, D elayed menarche, S tress fractures.

📌 Performance-Enhancing Aids (733)

🔍 Screening

Query at PPE, acne, striae, gynecomastia, testicular atrophy.

🧪 Diagnostic Tests

Urine drug screen (anabolic steroids), LFTs, lipids.

💊 Most Accurate Treatment

Cessation + counselling; no specific antidote.

🧠 Mnemonic

“STEROIDS” — S triae, T esticular atrophy, E motional lability, R educed HDL, O ra l/inj, I nfertility, D angerous.

📌 Specific Sports Injuries (734)

🔍 Screening

Pitch counts (baseball), heading rules (soccer), weight classification (wrestling).

🧪 Diagnostic Tests

Sport‑specific radiographs, MRI for overuse.

💊 Most Accurate Treatment

Little league elbow: rest 4-6 weeks; gymnast wrist: rest 6 weeks.

🧠 Mnemonic

“PITCH” — P rotect growth plate, I njury prevention, T hrowing limits, C ore stability, H eat acclimatization.

📌 Skeletal Dysplasias (735)

🔍 Screening

Disproportionate short stature, arm span/height ratio.

🧪 Diagnostic Tests

Skeletal survey, FGFR3/COL2A1 genetic testing.

💊 Most Accurate Treatment

Vosoritide (achondroplasia ≥5y); supportive care; growth hormone controversial.

🧠 Mnemonic

“RHIZO” — R hizomelic, H ydrocephalus (monitor), I nterpediculate narrowing, Z inc finger (trident), O besity prevention.

📌 Cartilage Matrix Proteins (736)

🔍 Screening

Myopia, cleft palate, hearing loss (Stickler), short trunk (SED).

🧪 Diagnostic Tests

COL2A1, COMP sequencing; ophthalmology exam.

💊 Most Accurate Treatment

Retinal detachment prevention (laser), hearing aids, joint replacement.

🧠 Mnemonic

“STICK” — S tickler (Pierre‑Robin), T runk shortening (SED), I rregular epiphysis, C ollagen gene, K niest (dumbbell).

📌 Transmembrane Receptors (737)

🔍 Screening

Rhizomelic shortening, macrocephaly, trident hand, hypercalcemia (Jansen).

🧪 Diagnostic Tests

FGFR3 (achondroplasia), PTHR1 sequencing, calcium level.

💊 Most Accurate Treatment

Vosoritide (achondroplasia); manage hypercalcemia in Jansen.

🧠 Mnemonic

“FGF” — F oramen magnum stenosis, G ains (gain‑of‑function), F ibroblast growth factor receptor 3.

📌 Ion Transporters (738)

🔍 Screening

Hitchhiker thumb, cauliflower ear, clubfoot, cleft palate (diastrophic).

🧪 Diagnostic Tests

SLC26A2 sequencing, radiographs.

💊 Most Accurate Treatment

Clubfoot surgery (resistant to Ponseti), cleft palate repair.

🧠 Mnemonic

“DTS” — D iastrophic dysplasia, T humb (hitchhiker), S ulfate transporter.

📌 Transcription Factors (739)

🔍 Screening

Bowed tibias (campomelic), absent clavicles (cleidocranial), iliac horns (nail‑patella).

🧪 Diagnostic Tests

SOX9, RUNX2, LMX1B sequencing; renal ultrasound (nail‑patella).

💊 Most Accurate Treatment

Supernumerary teeth extraction (cleidocranial), growth hormone (SHOX).

🧠 Mnemonic

“CLAP” — C leidocranial (clavicles), L MX1B (nail‑patella), A utosomal dominant, P ierre‑Robin (campomelic).

📌 Osteopetrosis (740)

🔍 Screening

Macrocephaly, hepatosplenomegaly, pancytopenia (infantile).

🧪 Diagnostic Tests

Radiograph (bone‑within‑bone), genetic (TCIRG1, CLCN7), acid phosphatase.

💊 Most Accurate Treatment

HSCT (for malignant ARO), calcitriol, interferon‑gamma.

🧠 Mnemonic

“MARBLE” — M arrow failure, A nemia, R adiodense, B lindness, L iver spleen, E ndobones.

📌 Other Inherited Disorders (741)

🔍 Screening

Polydactyly + heart defect (Ellis‑van Creveld), narrow thorax (Jeune), sparse hair (cartilage‑hair).

🧪 Diagnostic Tests

EVC/EVC2, DYNC2H1, RMRP sequencing; echocardiogram.

💊 Most Accurate Treatment

VEPTR for thoracic insufficiency; HSCT for cartilage‑hair hypoplasia (SCID).

🧠 Mnemonic

“JEC” — J eune (asphyxiating), E llis‑van Creveld (CHD), C artilage‑hair (immunodeficiency).

📌 Osteogenesis Imperfecta (742)

🔍 Screening

Blue sclerae, recurrent fractures, dentinogenesis imperfecta.

🧪 Diagnostic Tests

COL1A1/COL1A2 sequencing, bone biopsy, DXA.

💊 Most Accurate Treatment

IV pamidronate (bisphosphonate), rodding surgery, physical therapy.

🧠 Mnemonic

“BOW” — B lue sclera, O steopenia, W ormian bones.

📌 Marfan Syndrome (743)

🔍 Screening

Arm span/height ratio, wrist/thumb sign, ectopia lentis (upward).

🧪 Diagnostic Tests

Echocardiogram (aortic root), FBN1 sequencing, slit lamp.

💊 Most Accurate Treatment

Beta‑blocker/ARB (losartan), prophylactic aortic root replacement (≥50mm).

🧠 Mnemonic

“MARFAN” — M itral prolapse, A ortic dilation, R etinal detachment, F BN1, A rachnodactyly, N o contact sports.

📌 Ehlers-Danlos (744)

🔍 Screening

Beighton score, skin hyperextensibility, atrophic scars.

🧪 Diagnostic Tests

COL5A1/COL3A1 sequencing; urine deoxypyridinoline (kyphoscoliotic).

💊 Most Accurate Treatment

Physical therapy (hEDS); vascular EDS: celiprolol, avoid arteriography.

🧠 Mnemonic

“CLASS” — C lassical (scars), L axity, A rterial (vascular), S kin stretch, S cort (Beighton).

📌 Cutis Laxa (745)

🔍 Screening

Loose, sagging skin (inelastic), aged facies, occipital horns (X‑linked).

🧪 Diagnostic Tests

ELN, FBLN5, ATP7A sequencing; copper/ceruloplasmin.

💊 Most Accurate Treatment

Supportive; copper histidine for X‑linked.

🧠 Mnemonic

“CLX” — C uper deficiency, L axa (skin), X‑linked horns.

📌 Bone Regulation (746)

🔍 Screening

Growth curve, calcium/phosphate/ALP, vitamin D level.

🧪 Diagnostic Tests

PTH, 25(OH)D, 1,25(OH)2D, FGF23, renal function.

💊 Most Accurate Treatment

Vitamin D and calcium repletion; phosphate/calcitriol for hypophosphatemic rickets.

🧠 Mnemonic

“VIP” — V itamin D, I ntestine (Ca absorption), P TH (bone‑kidney).

📌 Hypophosphatasia (747)

🔍 Screening

Low serum ALP, premature tooth loss (root intact), rickets.

🧪 Diagnostic Tests

Elevated PLP (vit B6), urinary PEA, ALPL sequencing.

💊 Most Accurate Treatment

Asfotase alfa (enzyme replacement).

🧠 Mnemonic

“ALP” — A LP low, L ost teeth, P LP high.

📌 Hyperphosphatasia (748)

🔍 Screening

Incidental high ALP, post-viral (benign), bone deformity (juvenile Paget).

🧪 Diagnostic Tests

ALP isoenzymes, GGT normal (BTH), TNFRSF11B sequencing.

💊 Most Accurate Treatment

BTH: observation. Juvenile Paget: bisphosphonates.

🧠 Mnemonic

“BTH” — B enign, T ransient, H igh ALP (post‑viral).

📌 Osteoporosis (749)

🔍 Screening

Low‑impact fractures, back pain (vertebral), risk factors (steroids, malnutrition).

🧪 Diagnostic Tests

DXA (Z‑score ≤ -2.0), vertebral fracture assessment, calcium/vitamin D labs.

💊 Most Accurate Treatment

Calcium, vitamin D, weight‑bearing exercise; bisphosphonates (pamidronate) for severe cases.

🧠 Mnemonic

“FRACTURE” — F ragility, R isk factors (glucocorticoid), A ctivity (weight‑bearing), C alcium, T reat (bisphosphonates), U sual labs, R epeat DXA, E xercise.