🦠 Chapter 406: Viral Hepatitis

Nelson Textbook of Pediatrics 22nd Edition — Hepatitis A (HAV): fecal-oral, self-limited, vaccine-preventable. Hepatitis B (HBV): perinatal transmission, chronic infection risk inversely related to age, universal vaccination. Hepatitis C (HCV): direct-acting antivirals (DAAs) achieve >95% cure in children. Hepatitis D (HDV): coinfection/superinfection with HBV. Hepatitis E (HEV): waterborne, severe in pregnancy.

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📋 30 Clinical Scenarios — Viral Hepatitis

📇 High‑Yield Review Cards (Viral Hepatitis)

🩺 Clinical Presentations: Viral Hepatitis

Select a presentation for diagnostic clues and management.

📋 Stepwise Evaluation & Management of Viral Hepatitis

🔑 Key Principles — Viral Hepatitis (Nelson Ch.406)
• HAV: Anti-HAV IgM = acute infection. Supportive care. Post-exposure prophylaxis: vaccine or IG.
• HBV: HBsAg + anti-HBc IgM = acute; HBsAg >6 mo = chronic. Treat immune-active chronic hepatitis. Universal infant vaccination.
• HCV: Anti-HCV + HCV RNA. Direct-acting antivirals (DAAs) cure >95% in children ≥3 years.
• HDV: Requires HBV. Anti-HDV IgM. Prevention via HBV vaccine.
• HEV: Self-limited, high mortality in pregnancy. No vaccine in US.

    ⚡ Reflex Prompts — Viral Hepatitis Clinical Decisions

    📖 Viral Hepatitis — Core Summary (Nelson Ch.406)