๐ŸŽ—๏ธ Chapter 590 ยท Ovarian Malignancies in Children & Adolescents

Nelson Textbook of Pediatrics 22nd Edition โ€” Ovarian malignancies account for 1.3% of childhood cancers but 60-70% of gynecologic malignancies in this age group. Germ cell tumors (dysgerminoma, yolk sac, immature teratoma) are most common. Fertility-sparing surgery (unilateral salpingo-oophorectomy) is standard. Adjuvant BEP chemotherapy for advanced or high-risk disease. Excellent prognosis overall.

๐ŸŒ paeds.online โ€” Pakistan's Pediatric Platform

๐Ÿ“‹ 30 Clinical Scenarios โ€” Ovarian Malignancies

๐Ÿ“‡ Highโ€‘Yield Review Cards: Ovarian Malignancies

๐Ÿฉบ Clinical Presentations: Ovarian Malignancy

Select a presentation for diagnostic clues and management.

๐Ÿ“‹ Stepwise Management of Ovarian Malignancies

๐Ÿ”‘ Key Principles (Nelson Ch.590 โ€” Ovarian Malignancies)
โ€ข Germ cell tumors (GCT): Most common (dysgerminoma, yolk sac, immature teratoma). Excellent prognosis with fertility-sparing surgery + BEP.
โ€ข Tumor markers: AFP (yolk sac), ฮฒ-hCG (dysgerminoma, choriocarcinoma), LDH (dysgerminoma), inhibin (granulosa cell).
โ€ข Fertility-sparing surgery: Unilateral salpingo-oophorectomy + staging. Preserve contralateral ovary and uterus.
โ€ข Chemotherapy (BEP): Bleomycin, etoposide, cisplatin. For stage I yolk sac, stage IC dysgerminoma, and all advanced/recurrent.
โ€ข Sex cord-stromal tumors: Juvenile granulosa cell (estrogen โ†’ precocious puberty), Sertoli-Leydig (androgen โ†’ virilization).

    โšก Reflex Prompts โ€” Clinical Decisions

    ๐Ÿ“– Summary: Ovarian Malignancies in Children & Adolescents