🦟 Chapter 332 · African Trypanosomiasis (Sleeping Sickness)

Nelson Textbook of Pediatrics 22nd Edition | Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense (West/Central Africa, chronic) and T. b. rhodesiense (East/Southern Africa, acute). Transmitted by tsetse fly (Glossina). Stage 1 (hemolymphatic): fever, lymphadenopathy (Winterbottom sign), chancre. Stage 2 (meningoencephalitic): sleep disturbance (daytime somnolence, night insomnia), neurologic symptoms. Treatment depends on stage and subspecies: stage 1 β†’ pentamidine (gambiense) or suramin (rhodesiense); stage 2 β†’ NECT (nifurtimox-eflornithine) for gambiense, melarsoprol for rhodesiense. Without treatment, fatal.

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πŸ“‹ 30 Clinical Scenarios β€” African Trypanosomiasis

πŸ“‡ High‑Yield Review Cards (HAT)

🩺 Recognizing African Trypanosomiasis

Select a clinical presentation for diagnosis and management.

πŸ“‹ Step‑by‑Step Management of HAT

    πŸ’Š Treatment by Stage & Subspecies

    Subspecies & StageTreatment Regimen

    ⚑ Clinical Reflex Prompts β€” HAT

    πŸ“– Complete Summary: African Trypanosomiasis (Nelson Ch 332)