Nelson Textbook of Pediatrics 22nd Edition | Neonatal sepsis (GBS, E. coli, Listeria), empiric therapy by age, older children (S. pneumoniae, Hib, MRSA, Kingella), immunocompromised patients, ESKAPE pathogens, multidrug resistance (ESBL, CRE, VRE).
๐ paeds.online โ Pakistan's Pediatric Platform| Age Group | Common Pathogens | Empiric Antibiotics (IV) |
|---|---|---|
| Neonate (0-28 days) | GBS, E. coli, Listeria, HSV | Ampicillin + gentamicin (or cefotaxime) + acyclovir (if HSV risk) |
| Infant 1-3 months | GBS, E. coli, S. pneumoniae, HSV | Ampicillin + cefotaxime (or ceftriaxone if โฅ1 month) + acyclovir |
| 3 months - 5 years (fever without source) | S. pneumoniae, N. meningitidis, Hib (unvaccinated), E. coli (UTI) | Ceftriaxone (if ill-appearing); UA to r/o UTI |
| Older child (>5 years) | S. pneumoniae, S. pyogenes, Mycoplasma, S. aureus (MRSA) | Amoxicillin (pneumonia), azithromycin (atypical), vancomycin/cefazolin (MRSA/MSSA) |
| Immunocompromised/Neutropenic | Pseudomonas, Enterobacteriaceae, S. aureus, Candida, Aspergillus | Antipseudomonal ฮฒ-lactam (cefepime/meropenem) + vancomycin ยฑ antifungal |