🦠 Chapter 317 · Ebola & Other Viral Hemorrhagic Fevers

Nelson Textbook of Pediatrics 22nd Edition | Viral hemorrhagic fevers (VHFs) are severe illnesses caused by arenaviruses, bunyaviruses, filoviruses, and flaviviruses. Ebola virus disease (EVD) presents with fever, myalgia, vomiting, diarrhea, and hemorrhage in severe cases. Transmission via direct contact with body fluids. Treatment: supportive care, monoclonal antibodies (REGN-EB3, mAb114), and vesicular stomatitis virus-based vaccine (rVSV-ZEBOV). High mortality (50-90% without treatment). Strict infection control is critical.