Nelson Textbook of Pediatrics 22nd Edition | Salmonella Typhi and Paratyphi. Prolonged fever, rose spots, relative bradycardia, abdominal pain, intestinal perforation. MDR, XDR strains. Treatment: ceftriaxone, azithromycin, carbapenems (XDR). Prevention: vaccines (Vi polysaccharide, Ty21a, TCV).
🌐 paeds.online — Pakistan's Pediatric Platform| Resistance Pattern | Oral Option | IV Option | Duration |
|---|---|---|---|
| Susceptible | Azithromycin (10-14d) | Ceftriaxone (10-14d) | 10-14d |
| MDR (ampicillin, TMP-SMX, chloramphenicol) | Azithromycin (if susceptible) | Ceftriaxone | 10-14d |
| Fluoroquinolone-resistant | Azithromycin | Ceftriaxone | 10-14d |
| XDR (ceftriaxone-resistant + FQ-resistant + MDR) | Azithromycin (if susceptible) | Meropenem + azithromycin | 10-14d |