Nelson Textbook of Pediatrics 22nd Edition | Nocardiosis (N. asteroides, N. brasiliensis, N. nova), partially acid-fast filamentous bacteria, opportunistic infections in immunocompromised (CGD, transplant, HIV), pulmonary, cutaneous (mycetoma, lymphocutaneous), CNS, disseminated disease. Treatment: TMP-SMX, linezolid, amikacin, carbapenems.
๐ paeds.online โ Pakistan's Pediatric Platform| Species | Common Clinical Syndromes | Typical Resistance | Preferred Treatment |
|---|---|---|---|
| N. asteroides complex (most common) | Pulmonary, disseminated, CNS | Often susceptible to TMP-SMX, but some resistant | TMP-SMX + (amikacin or imipenem/meropenem for severe) |
| N. brasiliensis | Cutaneous (mycetoma, lymphocutaneous), pulmonary | May be resistant to TMP-SMX | TMP-SMX (often susceptible), amikacin, minocycline, linezolid |
| N. farcinica | Disseminated, pulmonary, CNS | Often resistant to TMP-SMX, ceftriaxone | Amikacin + imipenem/meropenem, linezolid |
| N. nova | Pulmonary, disseminated | Susceptible to TMP-SMX | TMP-SMX, linezolid |