📘 Niemann-Pick Disease · Types A, B, C

Nelson Textbook of Pediatrics 22nd Ed — Section 106.4. Types A/B (sphingomyelinase deficiency, SMPD1). Type C (NPC1/NPC2, cholesterol trafficking). Hepatosplenomegaly, cherry-red spot (type A), foam cells, vertical supranuclear gaze palsy (type C). Treatment: miglustat for NPC, ERT for type B (olipudase alfa).

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📋 30 Clinical Scenarios — Niemann-Pick Disease (FCPS level)

📇 High‑Yield Review Cards (Niemann-Pick Disease)

🩺 Symptom‑Based Approach: Niemann-Pick Disease

Select a presentation for diagnostic clues.

📋 Management of Niemann-Pick Disease

    ⚡ Reflex Prompts — Clinical Decisions in Niemann-Pick

    📖 Summary: Niemann-Pick Disease — Nelson 22nd Ed