🧬 Section 563.3 · Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Nelson Textbook of Pediatrics 22nd Edition | PKD1 (85%, chromosome 16) and PKD2 (15%, chromosome 4) mutations. Enlarged kidneys with macrocysts, hypertension, hematuria, proteinuria, extrarenal: hepatic cysts, intracranial berry aneurysms (5-10%), mitral valve prolapse. Tolvaptan (V2 receptor antagonist) in adults, ACE inhibitors, kidney transplantation.

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📋 30 Clinical Scenarios — Autosomal Dominant Polycystic Kidney Disease (Nelson 563.3)

📇 High‑Yield Review Cards — Genetics, Clinical Features, Management

🩺 ADPKD Clinical Explorer: genetics, presentation, extrarenal, management

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🔄 Stepwise Approach: Diagnosis and Management of ADPKD

    ⚡ Reflex Prompts — Clinical decisions in ADPKD

    📖 Summary: Autosomal Dominant Polycystic Kidney Disease — Nelson 22nd Ed (563.3)