Nelson Textbook of Pediatrics 22nd Edition | Acute eosinophilic pneumonia (AEP): acute respiratory failure, BAL eosinophils >25%, NO peripheral eosinophilia, associated with new smoking. Chronic eosinophilic pneumonia (CEP): subacute onset, peripheral eosinophilia, BAL eosinophils >40%, CXR: reverse pulmonary edema (peripheral infiltrates). Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss): asthma, eosinophilia, vasculitis, p-ANCA (MPO) in 40%. Allergic bronchopulmonary aspergillosis (ABPA): asthma/CF, central bronchiectasis, IgE >1000 IU/mL. Loeffler syndrome: parasitic (Ascaris), transient. Treatment: corticosteroids.
๐ paeds.online โ Pakistan's Pediatric Platform| Disease | Key Diagnostic Finding | Treatment |
|---|---|---|
| Acute eosinophilic pneumonia (AEP) | BAL eosinophils >25%, NO peripheral eosinophilia, new smoking | Methylprednisolone (1-2 mg/kg/day) or high-dose steroids, rapid improvement |
| Chronic eosinophilic pneumonia (CEP) | Peripheral eosinophilia, BAL >40%, peripheral infiltrates (reverse pulmonary edema) | Prednisone (0.5-1 mg/kg/day), may relapse, may need long-term/low-dose steroids |
| EGPA (Churg-Strauss) | Asthma, eosinophilia, vasculitis, p-ANCA (MPO) in 40% | Corticosteroids, cyclophosphamide for severe (renal, cardiac, neuropathy)|
| ABPA | Asthma/CF, central bronchiectasis, IgE >1000, Aspergillus IgE positive | Prednisone + itraconazole |
| Loeffler syndrome | Parasitic (Ascaris), transient infiltrates, eosinophilia | Anthelmintic (albendazole), corticosteroids if severe |