Nelson Textbook of Pediatrics 22nd Edition | Inherited disorders of dysregulated type I interferon (IFN) signaling. Aicardi-Goutières syndrome (AGS), STING-associated vasculopathy (SAVI), CANDLE (proteasome-associated), spondyloenchondrodysplasia, treatment with JAK inhibitors (baricitinib, tofacitinib).