Nelson Textbook of Pediatrics 22nd Edition | Primary testicular failure (hypergonadotropic hypogonadism). Causes: Klinefelter syndrome (47,XXY), anorchia, Noonan syndrome, chemotherapy/radiation, testicular torsion, cryptorchidism, autoimmune, Sertoli cell-only syndrome. Diagnosis: high LH/FSH, low testosterone. Treatment: testosterone replacement.
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