Nelson Textbook of Pediatrics 22nd Edition | Posterior Reversible Encephalopathy Syndrome (PRES): hypertension, immunosuppression (calcineurin inhibitors), eclampsia → headache, seizures, visual changes, vasogenic edema on MRI (parieto-occipital). Acute Necrotizing Encephalopathy (ANE): febrile illness → rapid encephalopathy, seizures, symmetric thalamic/brainstem/cerebellar lesions, RANBP2 mutations (ANE1), high mortality.
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